Model-based cardiovascular monitoring of large pore hemofiltration during endotoxic shock in pigs
نویسندگان
چکیده
Hemodynamic measurements were recorded every 30 minutes in 4 (porcine model) trials of 4 hours. Animals received a 0.5mg/kg endotoxin infusion over the first 30 minutes and underwent zero-balance continuous veno-venous filtration with 0.7m large pore substrate (80kDa cut-off) from 60 minutes onwards [1]. Subject-specific CVS models were fitted to 34 sets of data from the four trials. Each data set represents a minimal set of measurements available in an intensive care unit (ICU). Identified physiological model parameters and model outputs were compared to experimentally derived indices and measurements for validation.
منابع مشابه
Model-based identification and diagnosis of a porcine model of induced endotoxic shock with hemofiltration.
A previously validated cardiovascular system (CVS) model and parameter identification method for cardiac and circulatory disease states are extended and further validated in a porcine model (N=6) of induced endotoxic shock with hemofiltration. Errors for the identified model are within 10% when the model is re-simulated and compared to the clinical data. All identified parameter trends over tim...
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